Inclusion criteria for studies on PSVD - Paris PSVD Meeting

Inclusion criteria for studies on PSVD - Paris PSVD Meeting

by Laure Elkrief

Life & Natural Systems Medicine & Health MMedicine and NursingMJJHepatology
🎙 Laure Elkrief 👥 2K 📅 January 23, 2026 ⏱ 24 min 👁 23 📄 expert opinion 🧭 2026-08-16
Available in: English (current) Français

Keywords

PSVDliver biopsyportal hypertensioninclusion criteriacentral reading

Summary

The video presents a summary of discussions from a working group on inclusion criteria for studies on Porto-Sinusoidal Vascular Disease (PSVD). The group proposes that a liver biopsy is necessary for positive diagnosis, but for patients with major signs of portal hypertension and a biopsy less than 15 mm, liver stiffness measurement below 10 kPa can be used to exclude cirrhosis. Baseline characteristics for studies should include disease severity, presence of portal hypertension, liver-related complications, portal vein thrombosis, associated conditions, and distinction between possible and definite PSVD. For randomized controlled trials, stratification should be based on severe associated conditions and history of liver-related events. Central reading of liver biopsies is recommended, especially for trials, using a structured scoring system, and is necessary for pediatric studies. The discussion also addresses practical challenges such as digitalization, consent, and the need for expert centers.

141 words

Critical Evaluation

Value of the Information & Strength of the Argument

The video provides valuable insights into the complexities of defining inclusion criteria for rare liver diseases. The argumentation is solid, based on expert consensus and supported by data from published studies and an independent validation cohort. The speakers acknowledge uncertainties and propose pragmatic solutions, such as using liver stiffness as an alternative to biopsy in certain cases. The discussion is well-structured and addresses both scientific and practical considerations.

Scientific Rigor, Source Quality, Title Accuracy

The content demonstrates scientific rigor through reference to published data and validation in an independent cohort. The sources are not explicitly cited in the video, but the description mentions the FILFOIE network and the EURO-VALDI-NET, which are credible organizations. The title accurately reflects the content, focusing on inclusion criteria for PSVD studies. The video is a recording of a scientific meeting, so the quality is high, though it is based on expert opinion rather than a formal systematic review.

162 words

Title / Content Match

The title accurately reflects the content, which focuses on defining inclusion criteria for PSVD studies.

Quality & Reliability

8/10

The content is based on expert consensus from a specialized working group, with references to published data and validation in an independent cohort. The discussion is transparent about uncertainties and limitations.

Key Moments

Markers derived by PSI from the transcript: the creator did not define chapters.

Cited Sources

  • FILFOIE website — Mentioned in the video description as the organizing network.
  • EURO-VALDI-NET — Mentioned in the description as co-organizer of the meeting.

Concurring Sources

  • FILFOIE website — The network's mission aligns with the content of the video.

Contribution & Novelties

The video provides a novel consensus proposal for inclusion criteria in PSVD studies, addressing diagnostic challenges and practical considerations. It highlights the potential use of liver stiffness measurement to avoid repeat biopsies in certain patients, and emphasizes the importance of central reading for histology in trials.

Pour aller plus loin :

  • Porto-sinusoidal vascular disease — Overview of PSVD.
  • Liver stiffness measurement — Technique and clinical use.
  • Delphi method — Used for achieving consensus in the proposals.

76 words

Radar Profile

The radar profile shows high scores in information quantity, quality, and reliability, with a slightly lower technical level, indicating a well-balanced presentation suitable for a professional audience.

Reliability 8/10