Séminaire de recherche PACRI - N°25 - 27.06.2025

Séminaire de recherche PACRI - N°25 - 27.06.2025

🎙 MESuRS Cnam 👥 334 📅 August 26, 2025 ⏱ 62 min 👁 48 📄 original study 🧭 2026-08-15
Available in: English (current) Français

Keywords

HBVliver fibrosisAPRIantibiotic stewardshipinterrupted time series

Summary

This research seminar features two presentations. The first, by Nicole Kamikazi, investigates delays in diagnostic tests for hepatitis B-related liver diseases in Burkina Faso. The study, a retrospective cohort of 609 patients, found that while over 80% eventually completed key tests like FibroScan and HBV DNA, the median time to complete all five required tests was 400 days. The APRI score, recommended by WHO when FibroScan is unavailable, showed low sensitivity (39.5%) overall, but sensitivity improved when tests were done within 3 days. The study also compared treatment eligibility criteria, finding that WHO 2024 guidelines would lead to overtreatment compared to European criteria, while alternative criteria like TREAT-B and HepSet showed better concordance. The second presentation, by Satria Nur Syaban, examines determinants of antibiotic resistance in hospital settings, focusing on the impact of an antimicrobial stewardship intervention on antibiotic consumption and microbial profiles. Using interrupted time series analysis, the study found significant step changes in the use of specific antibiotics like cefotaxime and ceftriaxone post-intervention, with effects persisting. The presentation was cut short due to technical issues, but initial results suggest the intervention was successful.

185 words

Critical Evaluation

Value of the Information & Strength of the Argument

The first presentation provides valuable insights into the real-world challenges of hepatitis B diagnosis in resource-limited settings. The study’s use of a retrospective cohort and survival analysis is appropriate, and the findings on diagnostic delays are significant. The argumentation is solid, with clear links between delays and reduced diagnostic accuracy. The second presentation, though incomplete, demonstrates a rigorous approach using interrupted time series analysis to evaluate an antimicrobial stewardship intervention. The initial results are promising, but the presentation was cut short, limiting the depth of the argumentation.

Scientific Rigor, Source Quality, Title Accuracy

The presentations demonstrate scientific rigor with clear methodologies and statistical analyses. The first study references WHO guidelines and other treatment criteria, but specific sources are not cited in the video. The second study mentions previous work in the same hospital, but details are sparse. The title accurately reflects the seminar’s content. No comments were provided for analysis.

159 words

Title / Content Match

The title accurately reflects the content: a research seminar with two presentations on health-related topics.

Quality & Reliability

7/10

The seminar presents two original research studies with clear methodology, statistical analysis, and discussion of limitations. However, the video is a recording of a seminar with limited production quality, and the second presentation is incomplete due to technical issues.

Key Moments

Contribution & Novelties

The first study provides novel data on diagnostic delays for HBV in Burkina Faso, highlighting the negative impact of delays on APRI accuracy. It also evaluates the performance of WHO 2024 treatment criteria in an African setting, suggesting potential overtreatment. The second study, though incomplete, adds to the evidence on antimicrobial stewardship interventions in low-resource settings.

Pour aller plus loin :

  • WHO guidelines for hepatitis B — Official WHO guidelines for hepatitis B prevention and care.
  • APRI score — Clinical calculator for APRI score.
  • Antimicrobial stewardship — WHO page on antimicrobial resistance and stewardship.

94 words

Radar Profile

The radar profile shows high scores in information quantity and quality, with moderate technical level and reliability. This indicates a content-rich seminar with solid scientific content, though the technical depth is not extremely high.

Reliability 7/10