Infection by Brevundimonas spp. in immunocompromised children: report of two cases

Infection by Brevundimonas spp. in immunocompromised children: report of two cases

by Dr. Christian Manuel Chiara Chilet

Life & Natural Systems Medicine & Health MJCDiseases and disordersMJCJInfectious and contagious diseases
🎙 Dr. Christian Manuel Chiara Chilet 👥 767 📅 November 4, 2025 ⏱ 23 min 👁 17 📄 original study 🧭 2026-08-13
Available in: English (current) Français

Keywords

Brevundimonasimmunocompromisedcase reportneutropenic feverantimicrobial resistance

Summary

This presentation, part of a scientific dissemination series, reports two cases of Brevundimonas spp. infection in immunocompromised children. The first case is a 5-year-old girl with Down syndrome, monoreno, and hypothyroidism, who developed neutropenic fever after chemotherapy for a hematologic malignancy. Blood cultures grew Brevundimonas aurantiaca, identified by 16S rRNA gene sequencing. The patient was treated with meropenem after initial therapy failed, with a favorable outcome. The second case is a 1-year-9-month-old girl with hepatoblastoma and pulmonary nodules, who also developed neutropenic fever after chemotherapy. Blood cultures grew Brevundimonas spp. (species not identified). She was treated with meropenem for 14 days, with a favorable response. The presentation discusses the microbiology of Brevundimonas, its opportunistic nature, and the importance of antimicrobial stewardship and infection control measures. It emphasizes the need for molecular identification in unusual pathogens and highlights the role of hand hygiene, contact precautions, and environmental cleaning in preventing infections. The speaker also answers questions about laboratory identification, transmission, and comparison with tuberculosis.

163 words

Critical Evaluation

Value of the Information & Strength of the Argument

The value of the information is high for clinicians, as it provides detailed clinical data on a rare pathogen and its management. The argumentation is solid, based on a peer-reviewed case report and supported by microbiological data. The speaker clearly explains the clinical decision-making process, including empirical therapy and escalation based on susceptibility testing. The discussion of prevention strategies is evidence-based, referencing a 2024 review on multimodal interventions. The presentation is well-structured and informative.

83 words

Title / Content Match

The title accurately reflects the content: a case report of Brevundimonas spp. infections in two immunocompromised children.

Quality & Reliability

8/10

Presentation of a peer-reviewed case report published in a Scopus-indexed journal, with detailed clinical data and molecular identification. The speaker is an infectious disease specialist with relevant credentials. Limitations include the small number of cases and the lack of a control group.

Key Moments

Markers derived by PSI from the transcript: the creator did not define chapters.

Cited Sources

  • Case report: Infection by Brevundimonas spp. in immunocompromised children — The case report was published in this journal, which is indexed in Scopus.
  • 2024 review on multimodal infection control strategies — Referenced in the presentation as a source for multimodal strategies to reduce multidrug-resistant organisms.

Concurring Sources

  • Brevundimonas spp. infections in immunocompromised patients — The presentation aligns with existing literature on opportunistic infections in immunocompromised hosts.

Contribution & Novelties

This presentation adds to the limited literature on Brevundimonas infections in pediatric immunocompromised patients. It provides detailed clinical and microbiological data from two cases, including molecular identification of one isolate. The discussion on prevention and antimicrobial stewardship is valuable for clinical practice.

Pour aller plus loin :

89 words

Radar Profile

The radar profile shows high scores in quality and reliability, with moderate scores in quantity and technical level. This indicates a focused, well-supported presentation with room for more comprehensive coverage.

Reliability 8/10

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